Search results for "Redox active"

showing 6 items of 6 documents

Molecular Strategies for Targeting Antioxidants to Mitochondria: Therapeutic Implications

2015

Mitochondrial function and specifically its implication in cellular redox/oxidative balance is fundamental in controlling the life and death of cells, and has been implicated in a wide range of human pathologies. In this context, mitochondrial therapeutics, particularly those involving mitochondria-targeted antioxidants, have attracted increasing interest as potentially effective therapies for several human diseases. For the past 10 years, great progress has been made in the development and functional testing of molecules that specifically target mitochondria, and there has been special focus on compounds with antioxidant properties. In this review, we will discuss several such strategies, …

AntioxidantPhysiologyPlant AlkaloidsCellsAntioxidant propertiesmedicine.medical_treatmentClinical BiochemistryApoptosisContext (language use)Oxidative phosphorylationBiologyMitochondrionBiochemistryCellular redox/oxidative balanceAntioxidantsComprehensive Invited ReviewAutophagymedicineAnimalsHumansRedox activeMolecular BiologyGeneral Environmental ScienceHuman pathologiesAutophagyRedox active moleculesCell BiologyMitochondriaCell biologyBiochemistryGeneral Earth and Planetary SciencesMitochondrial functionTesting of moleculesOxidation-ReductionFunction (biology)Antioxidants & Redox Signaling
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Tetrathiafulvalene-based molecular nanowires.

2008

A new molecular wire suitably functionalized with sulfur atoms at terminal positions and endowed with a central redox active TTF unit has been synthesized and inserted within two atomic-sized Au electrodes; electrical transport measurements have been performed in STM and MCBJ set-ups in a liquid environment and reveal conductance values around 10(-2) G0 for a single molecule.

ChemistryMetals and AlloysNanowirechemistry.chemical_elementConductanceNanotechnologyGeneral ChemistrySettore CHIM/06 - Chimica OrganicaSulfurCatalysisSurfaces Coatings and FilmsElectronic Optical and Magnetic MaterialsMolecular wireCrystallographychemistry.chemical_compoundElectrodeMaterials ChemistryCeramics and CompositesRedox activeMoleculeMolecular wiresTetrathiafulvaleneChemical communications (Cambridge, England)
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Facile access to foldable redox-active flavin-peptide conjugates

2021

A convenient approach for the synthesis of foldable redox-active flavin peptide conjugates was established. A model β-hairpin oligopeptide motif was utilized to demonstrate that azidolysine side-chains are readily functionalised with an alkyne-bearing flavine derivative. The folding equilibrium of the peptide backbone as well as the redox behaviour of the flavin moieties remains intact after the conjugation.

chemistry.chemical_classificationOligopeptideChemistryOrganic ChemistryPeptideFlavin groupBiochemistryRedoxCombinatorial chemistryFolding (chemistry)chemistry.chemical_compoundRedox activeheterocyclic compoundsPhysical and Theoretical ChemistryPeptidesDerivative (chemistry)Conjugate
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Host molecules containing electroactive cavities obtained by the molecular assembly of redox-active ligands and metal ions

1995

Self-assembly processes of nickel ions with the redox-active ligand 1,4,8,11-tetra(ferrocenylmethyl)-1,4,8,11-tetraazacyclotetradecane (Fc4cyclam) induces the formation of a redox-active cavity of potential use in electrocatalysis.

ChemistryLigandMetal ions in aqueous solutionInorganic chemistryMolecular MedicineMoleculeRedox activeNickel ionsElectrocatalystCombinatorial chemistryJ. Chem. Soc., Chem. Commun.
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[Fe(sal2-trien)][Ni(dmit)2]: towards switchable spin crossover molecular conductors

2004

A cooperative spin transition behaviour with a wide hysteresis loop (30 K) around 240 K has been observed, for the first time, in a salt based on the redox active [Ni(dmit)2]¯, anion and the [Fe(sal2-trien)]+ spin crossover cation. Real Cabezos, Jose Antonio, Jose.A.Real@uv.es

UNESCO::QUÍMICASpin transitionSalt (chemistry)Mineralogy:QUÍMICA [UNESCO]Fe(sal2-trien)][Ni(dmit)2CatalysisIonSpin crossoverMaterials ChemistryRedox activeElectrical conductorchemistry.chemical_classificationMolecular conductorsUNESCO::QUÍMICA::Química inorgánicaMolecular conductors ; Spin transition ; Salt based ; Fe(sal2-trien)][Ni(dmit)2Metals and AlloysSpin transitionSalt basedGeneral Chemistry:QUÍMICA::Química inorgánica [UNESCO]Surfaces Coatings and FilmsElectronic Optical and Magnetic MaterialsCrystallographychemistryCeramics and CompositesChemical Communications
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Stabilization and detection of hydrophylloquinone as di-O-methyl derivative

2016

Phylloquinone is a redox active naphthoquinone involved in electron transport in plants. The function of this reduced form remains unclear due to its instability, which has precluded detection. Herein, a simple method that permits the stabilization of the reduced form of phylloquinone by di-O-methylation and HPLC detection is described. Fil: Sussmann, Rodrigo A. C.. Universidade de Sao Paulo; Brasil Fil: de Moraes, Marcilio M.. Universidade de Sao Paulo; Brasil Fil: Cebrián Torrejón, Gerardo. Universidad de Valencia; España. Universidade de Sao Paulo; Brasil Fil: Porta, Exequiel Oscar Jesús. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - …

0301 basic medicineClinical BiochemistryNanotechnologyElectrochemistryBiochemistryHigh-performance liquid chromatographyRedoxMethylationHydrophylloquinoneAnalytical ChemistryELECTROCHEMISTRY03 medical and health scienceschemistry.chemical_compoundHYDROPHYLLOQUINONEElectrochemistryRedox activeChromatography High Pressure LiquidChromatographyREDOXMethyl derivativeCiencias QuímicasCROMATOGRAFIA LÍQUIDA DE ALTA EFICIÊNCIACell BiologyGeneral MedicineVitamin K 1Combinatorial chemistryElectron transport chainNaphthoquinoneDI-O-METHYL DERIVATIVE030104 developmental biologychemistryPHYLLOQUINONEQuímica AnalíticaHPLCCIENCIAS NATURALES Y EXACTAS
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